This report has been prepared by nicnas using a range of sources, including. In this paper, we report several methods used for synthesizing this acid. Final report on the safety assessment of sorbic acid and. Dehydroacetic acid sodium salt stability in cosmetic. Benzyl alcohol is metabolized to benzoic acid, which reacts with glycine and excreted as hippuric acid in the human body. Small oral doses 2070 mgkg of c 14dha were not rapidly excreted. Overview kemaben dha is a liquid system with broad spectrum antimicrobial activity based on well accepted and safe cosmetic preservatives. Final report on the safety assessment of glycolic acid.
Dehydroacetic acid and its derivatives 1st edition. Dehydroacetic acid definition of dehydroacetic acid by. The cir expert panel evaluated the scientific data and concluded that dehydroacetic acid and sodium dehydroacetate were safe as cosmetic ingredients in the present practices of use and concentration. Ewgs skin deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Inci composition phenoxyethanol methylparaben dehydroacetic acid 2. It presents as an odorless, colorless to white crystalline powder, almost insoluble in water and moderately soluble in most organic solvents. Cir compendium, containing abstracts, discussions, and conclusions of cir cosmetic ingredient safety assessments. Dehydroacetic acid dha journal of pharmacology and.
The cir expert panel noted that sodium dehydroacetate and dehydroacetic acid are effective antimicrobials at low concentrations less than and equal to 0. Pesticide properties for dehydroacetic acid, including approvals, environmental fate, ecotoxicity and human health issues. Sorbic acid is a straightchain monocarboxylic acid used in cosmetic formulations as a preservative at concentrations up to 1. These polyurethane copolymers are a highly heterogeneous group of structures created from diverse diisocyanate, glycol, and carboxylic acid. Until these data are available, it is concluded that the available data. Dehydroacetic acid is an organic compound, pyrone derivative with a wide variety of different applications in many important key industries. Fungicides have the ability to kill continue reading sodium. It is more likely to prevent them from growing in products than killing them off though. No evidence of tumor induction by dehydroacetic acid was detected in a 64week study. No evidence of mutagenicity was reported for either ingredient use.
Dehydroacetic acid drug information, uses, side effects. Benzoic acid is an aromatic acid used in a wide variety of cosmetics as a ph adjuster and preservative. Environmental risk assessment guidance manual for industrial chemicals. In cosmetics and personal care products, dehydroacetic acid and. Final report on the safety assessment of benzyl alcohol.
Sorbic acid and potassium sorbate were practically nontoxic to rats and mice in acute oral toxicity studies. Dha administered orally to rabbits at a dose level of 250 mgkg did not increase the urinary excretion of glucuronides or ethereal sulfates. Final report on the safety assessment of sorbic acid. Article information, pdf download for 4 final report on the safety. Dehydroacetic acid dha labeled with c 14 in four carbon atoms has been synthesized. These ingredients are more likely to act by preventing the growth of microbes, rather than killing the microbes. It is an optimised blend which combines the activity of different groups of compounds. This report describes the results of the project, including a survey of the market and the results of.
Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Nonopen access articles that fall outside this five year window are available only to institutional subscribers and current aspet members, or through the article purchase feature at the bottom of the page. It is designated as safe for general or specific, limited use in food. A preliminary report on the antimicrobic properties of dehydroacetic acid. Japan maximum level of dehydroacetic acid should be 0.
Dehydroacetic acid is the cyclic ketone that conforms to the formula. Aug 25, 2017 this report describes the analysis of three kinds of food preservatives, benzoic acid, sorbic acid and dehydroacetic acid, according to the testing method for food additives described in the standard methods of analysis for hygienic chemistry. Reactivity of dehydroacetic acid in organic synthesis. Benzyl alcohol, sodium benzoate, dehydroacetic acid. Repeatability of 100 ugml preservative standards spiked in juice sample 5 runs with the first run excluded sorbic dehydroacetic benzoic acid acid acid c 8h 8o 3 c 9h 10o 3 c 10h 12o 3 c 11h 14o 3 area mean 841031. Dehydroacetic acid dha, benzoic acid ba, sorbic acid soa, salicylic acid sa and their sodium salts have been widely used as antimicrobial agents in pharmaceuticals and cosmetics because of their broad antimicrobial spectrum with good stability and nonvolatility. Sodium dehydroacetate, dehydroacetic acid, and cosmetics containing. Sometimes its salt form known as sodium dehydroacetate is used, as it is more soluble in certain types of cosmetic formulas. Dehydroacetic acid and its derivatives are widely used as an intermediates in organic synthesis. Anonymous 1990 final report on the safety assessment of phenoxyethanol. Final report safety assessment of malic acid and sodium maiate a.
Benzoic acid, sorbic acid, dehydroacetic acid 2 gml each in water the chromatogram of standard mixture displayed in fig. Jpet articles become freely available 12 months after publication, and remain freely available for 5 years. Useful synthons in organic synthesis outlines the use of dha and its derivatives for the synthesis of pharmacologically active heterocyclic compounds. Nov 10, 2012 dehydroacetic acid is a preservative with mild antibacterial properties thats most effective against fungi. Sodium dehydroacetate and dehydroacetic acid are used as preservatives in cosmetic formulations at concentrations of 1. Download safety assessment of imidazolidinyl urea as used in. Prevent the products used to fight the fire from going into drains, sewers, or waterways. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelflife by preventing microbial contamination. Dehydroacetic acid skin deep cosmetics database ewg.
The ansm report evaluation du risque lie a lutilisation du phenoxyethanol dans les produits cosmetiques concludes that the maximum authorised concentration currently of 1% of phenoxyethanol for use as a preservative should be lowered to 0. In subchronic studies no significant adverse effects were observed in rats, mice, or dogs when 10% sorbic acid was included in the diet. Hence, the simultaneous determination of these preservatives in. Side effects dehydroacetic acid is generally considered to be safe. Sodium dehydroacetate and dehydroacetic acid are used as preservatives in cosmetic. Dehydroacetic acid is characterized as a white to cream crystalline powder. Dehydroacetic acid sodium salt stability in cosmetic preservative mixtures. Both compounds are rapidly absorbed when administered orally or on the skin of test animals. Benzyl alcohol and dehydroacetic acid cosmetic science talk. Usa safe for cosmetic ingredient in the present practices of use and concentration. Analysis of preservative additives in food by agilent 7820a gc. Sodium benzoate is the sodium salt of benzoic acid used as a preservative, also in a wide range of cosmetic product types.
Use water to cool tanks, cisterns, or containers close to the heat source or fire. Origin sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Know about technical details of dehydroacetic acid like. Thanks to its preserving and stabilizing qualities, dehydroacetic acid, main application is in the cosmetic and personal care industry, as well as food industry, according to local regulation. The metabolism of dehydroacetic acid dha sciencedirect. In 2003, the cir expert panel considered available new data on dehydroacetic acid and sodium dehydroacetate and reaffirmed the above conclusion. Dehydroacetic acid had an inhibitory effect on hepatoma induction in rats when fed 4dimethylaminoazobenzene. Rapport konserveringsmidler i kosmetiske produkter miljostyrelsen. Dehydroacetic acid is an organic compound which has several industrial applications. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient dehydroacetic acid. Dehydroacetic acid and sodium dehydroacetate are tasteless, odorless white powders. Based on the available information included in this report, the cir expert panel concluded that glycolic and lactic acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations.
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